Selected Publications in Category - HGE (human granulocytic ehrlichiosis) Agent :      Back to Publications Page   

1. Rikihisa, Y., M. Lin, H. Niu, and Z. Cheng. (2009) Type IV Secretion System of Anaplasma phagocytophilum and Ehrlichia chaffeensis. In: Rickettsiology and Rickettsial Diseases-Fifth International Conference. Edited by Karim E. Hechemy; Philippe Brouqui; James E. Samuel; and Didier A. Raoult. Ann. N. Y. Acad. Sci. 1166: 106-111. [Link to Pubmed]
2. Lai, T.H., Y. Kumagai, M. Hyodo, Y. Hayakawa, and Y. Rikihisa. (2009) The Anaplasma phagocytophilum PleC histidine kinase and PleD diguanylate cyclase two-component system and role of cyclic Di-GMP in host cell infection. [Comment in: J Bacteriol. 2009 Feb;191(3):683-6] J. Bacteriol. 191: 693-700. [PMCID: PMC2632110] | [Link to Pubmed]
3. Xiong, Q., M. Lin, and Y. Rikihisa. (2009) Anaplasma phagocytophilum acquires cholesterol through low-density lipoprotein uptake pathway. PLoS Pathog. 5: e1000329. [PMCID: PMC2654415] | [Link to Pubmed]
4. Mottaz-Brewer, Heather M., A. D. Norbeck, J. N. Adkins, N. P. Manes, C. K. Ansong, L. Shi, Y. Rikihisa, T. Kikuchi, S. W. Wong, R. D. Estep, F. Heffron, L. Pasa-Tolic, and R. D. Smith. (2008) Optimization of proteomic sample preparation procedures for comprehensive protein characterization of pathogenic systems. J. Biomol. Tech. 19: 285-295. [PMCID: PMC2628077] | [Link to Pubmed]
5. Xiong, Q., X. Wang, and Y. Rikihisa. (2007) High-Cholesterol Diet Facilitates Anaplasma phagocytophilum Infection and Up-regulates MIP-2 and CXCR2 Expression in Apolipoprotein E-Deficient Mice. J. Infect. Dis. 195: 1497-1503. [Link to Pubmed]
6. Huang, H., X. Wang, T. Kikuchi, Y. Kumagai, and Y. Rikihisa. (2007) Porin Activity of Anaplasma phagocytophilum Outer Membrane Fraction and Purified P44. J. Bacteriol. 189: 1998-2006. [PMCID: PMC1855737] | [Link to Pubmed]
7. Lin, M., A. den Dulk-Ras, P. JJ Hooykaas, and Y. Rikihisa (2007) Anaplasma phagocytophilum AnkA Secreted by Type IV Secretion System is Tyrosine Phosphorylated by Abl-1 to Facilitate Infection. Cell. Microbiol. 9: 2644-2657. [Link to Pubmed]
8. Wang, X., T. Kikuchi, and Y. Rikihisa. (2007) Proteomic Identification of A Novel Anaplasma phagocytophilum DNA Binding Protein That Regulates A Putative Transcription Factor. J. Bacteriol. 189: 4880-4886. [PMCID: PMC1913470] | [Link to Pubmed]
9. Niu, H., M. Yamaguchi, and Y. Rikihisa (2007) Subversion of cellular autophagy by Anaplasma phagocytophilum. Cell. Microbiol. 10: 593-605.  [Link to Pubmed]
10. Ge, Y. and Y. Rikihisa. (2007) Identification of Novel Surface Proteins of Anaplasma phagocytophilum by Affinity Purification and Proteomics. J. Bacteriol. 189: 7819-7828. [PMCID: PMC2168727] | [Link to Pubmed]
11. Wang, X., Z. Cheng, C. Zhang, T. Kikuchi, and Y. Rikihisa (2007) Anaplasma phagocytophilum p44 mRNA expression is differentially regulated in mammalian and tick host cells: Involvement of the DNA binding protein ApxR. J. Bacteriol. 189: 8651-8659. [PMCID: PMC2168941] | [Link to Pubmed]
12. Kawahara, M, Y. Rikihisa, Q. Lin, E. Isogai, K. Tahara, A. Itagaki, Y. Hiramitsu, and T. Tajima. (2006) Genetic variants of Anaplasma phagocytophilum, Anaplasma bovis, Anaplasma centrale and Ehrlichia species in wild deer on two major islands in Japan. Appl. Environ. Microbiol. 72: 1102-1109. [PMCID: PMC1392898] | [Link to Pubmed]
13. Cheng, Z., Y. Kumagai, M. Lin, C. Zhang, and Y. Rikihisa. (2006) Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cell. Microbiol. 8: 1241-1252.  [Link to Pubmed]
14. Ge, Y. and Y. Rikihisa. (2006) Anaplasma phagocytophilum delays spontaneous human neutrophil apoptosis by modulation of multiple apoptotic pathways. Cell. Microbiol. 8: 1406-1416.  [Link to Pubmed]
15. Wang, X., T. Kikuchi, and Y. Rikihisa (2006) Two monoclonal antibodies with defined epitopes of P44 major surface proteins neutralize Anaplasma phagocytophilum by distinct mechanisms. Infect. Immun. 74: 1873-1882. [PMCID: PMC1418626] | [Link to Pubmed]
16. Lin, Q. C. Zhang, and Y. Rikihisa (2006) Analysis of Involvement of the RecF Pathway in p44 Recombination in Anaplasma phagocytophilum and in Escherichia coli by Using a Plasmid Carrying the p44 Expression and p44 Donor Loci. Infect. Immun. 74: 2052-2062. [PMCID: PMC1418890] | [Link to Pubmed]
17. Niu, H., Y. Rikihisa, M. Yamaguchi, and N. Ohashi (2006) Differential Expression of VirB9 and VirB6 During Lifecycle of Anaplasma phagocytophilum in Human Leukocytes is Associated with Differential Binding and Avoidance of Lysosome Pathway. Cell. Microbiol. 8: 523-534.  [Link to Pubmed]
18. Rikihisa, Y. (2006) Ehrlichia subversion of host innate immune responses. Curr. Opin. Microbiol. 9: 95-101.  [Link to Pubmed]
19. Dunning Hotopp, J., M. Lin, R. Madupu, J. Crabtree, S. Angiuoli, J. Eisen, R. Sesahdri, Q. Ren, T. R. Utterback, S. Smith, M. Lewis, H. Khouri, C. Zhang, H. Niu, Q. Lin, N. Ohashi, N. Zhi, W. Nelson, L. M. Brinkac, R. J. Dodson, M. J. Rosovitz, J. Sundaram, S. C. Daugherty, T. Davidsen, A. Durkin, M. Gwinn, D. H. Haft, J. D. Selengut, S.A. Sullivan, N. Zafar, L. Zhou, F. Benahmed, H. Forberger, R. Halpin, S. Mulligan, J. Robinson,Y. Rikihisa, H. Tettelin. (2006) Comparative Genomics of Emerging Human Ehrlichioisis Agents. PLoS Genetics 2: e21. [PMCID: PMC1366493] | [Link to Pubmed]
20. Ge, Y., K. Yoshiie, F. Kuribayashi, M. Lin, and Y. Rikihisa. (2005) Anaplasma phagocytophilum inhibits human neutrophil apoptosis via upregulation of bfl-1, maintenance of mitochondrial membrane potential, and prevention of caspase 3 activation. Cell. Microbiol. 7: 29-38.  [Link to Pubmed]
21. Lin, Q. and Y. Rikihisa. (2005) Establishment of cloned Anaplasma phagocytophilum and analysis of p44 Gene conversion within infected horse and SCID mice. Infect. Immun. 73: 5106-5114. [PMCID: PMC1201200 ] | [Link to Pubmed]
22. Lin, Q., Y. Rikihisa, S. Felek, X. Wang, R. F. Massung, and Z. Woldehiwet. (2004) Anaplasma phagocytophilum has functional msp2 distinct from p44s. Infect. Immun. 72: 3883-3889.  [Link to Pubmed]
23. Lin, Q., Y. Rikihisa. R. F. Massung, and Z. Woldehiwet. (2004) p44 polymorphism and transcription in a unique genomic locus in Anaplasma phagocytophilum strains from diverse geographic regions. Infect. Immun. 72: 5574-5581.  [Link to Pubmed]
24. Felek, S., S.Telford IIIrd, R. C. Falco, and Y. Rikihisa (2004) Sequence analysis of p44 homologs expressed by Anaplasma phagocytophilum in infected ticks feeding on naïve hosts and in mice infected by tick attachment Infect. Immun. 72: 659-666.  [Link to Pubmed]
25. Wang, X., Y. Rikihisa, T. Lai, Y. Kumagai, N. Zhi, and S. M. Reed. (2004) Rapid sequential changeover of expressed p44 genes during the acute phase of Anaplasma phagocytophilum infection in horses. Infect. Immun. 72: 6852-6859. [PMCID: PMC529143] | [Link to Pubmed]
26. Lin, M., and Y. Rikihisa. (2003) Ehrlichia chaffeensis and Anaplasma phagocytophilum Lack Genes for Lipid A Biosynthesis and Incorporate Cholesterol for Their Survival. Infect. Immun. 71: 5324-5331. [PMCID: PMC187327] | [Link to Pubmed]
27. Lin, Q., Y. Rikihisa, N. Ohashi, and N. Zhi. (2003) Mechanisms of Variable p44 Expression by Anaplasma phagocytophilum. Infect. Immun. 71: 5650-5661.  [Link to Pubmed]
28. Lin, M., and Y. Rikihisa. (2003) Obligatory intracellular parasitism by Ehrlichia chaffeensis and Anaplasma phagocytophilum involves caveolae and glycosylphosphatidylinositol-anchored proteins. Cell. Microbiol. 5: 809-820.  [Link to Pubmed]
29. Kim, H-Y. J. Mott, N. Zhi, T. Tajima, Y. Rikihisa. (2002) Cytokine Gene Expression by Peripheral Blood Leukocytes in Horses During Experimental Infection with Anaplasma phagocytophila. Clin. Diag. Lab. Immunol. 9: 1079-1084.  [Link to Pubmed]
30. Zhi, N., N. Ohashi, T. Tajima, J. Mott, R. W. Stich, D. Grover, S. R. Telford III, Q. Lin, and Y. Rikihisa. (2002) Transcript Heterogeneity of p44 Multigene Family in Human Granulocytic Ehrlichiosis Agent Transmitted by Ticks. Infect. Immun. 70: 1175-1184.  [Link to Pubmed]
31. Zhi, N., N. Ohashi, and Y. Rikihisa. (2002) Activation of a p44 pseudogene in Anaplasma phagocytophila by bacterial RNA splicing: A novel mechanism for posttranscriptional regulation of a multigene family encoding immunodominant major outer membrane proteins. Mol. Microbiol. 46: 135-146.  [Link to Pubmed]
32. Mott, J., Y. Rikihisa and S. Tsunawaki. (2002) Effects of Anaplasma phagocytophila on NADPH Oxidase Components in Human Neutrophils and HL-60 cells. Infect. Immun. 70: 1359-1366.  [Link to Pubmed]
33. Ohashi, N., N. Zhi, Q. Lin, and Y. Rikihisa. (2002) Characterization and Transcriptional Analysis of Gene Clusters for a Type IV Secretion Machinery in Human Granulocytic and Monocytic Ehrlichiosis Agents. Infect. Immun. 70: 2128-2138.  [Link to Pubmed]
34. Lin, Q. N. Zhi, N. Ohashi, H. W. Horowitz, M.E. Aguero-Rosenfeld, J. Ruffalli, G. P.Wormser, and Y. Rikihisa. (2002) p44 Gene Expression by Anaplasma phagocytophila in Acutely Infected Patients. J. Clin. Microbiol. 40: 2981-2988.  [Link to Pubmed]
35. Kim, Y-H, and Y. Rikihisa. (2002) Proinflammatory Cytokine mRNA Expression in Human Peripheral Blood Leukocytes in Response to Anaplasma phagocytophila through Activation of Nuclear Factor-kB and p38 Mitogen-Activated Protein Kinase. Infect. Immun. 70: 4132-4141.  [Link to Pubmed]
36. Dumler, J.S., A.F. Barbet, C.P.J. Bekker, G.A. Dasch, G.H. Palmer, S.C. Ray, Y. Rikihisa, and F. R. Rurangirwa. (2001) Reorganization of Genera in the Families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales; Unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia, and Ehrlichia with Neorickettsia; Description of six new species combinations; and Designation of Ehrlichia equi and "HGE agent" as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51: 2145-2165.  [Link to Pubmed]
37. Unver, A., S. Felek, N. Zhi, C. Paddock, H. W. Horowitz, G. P.Wormser, and Y. Rikihisa. (2001) Western Immunoblot Analysis of HME and HGE dual reactive sera. J. Clin. Microbiol. 39: 3982-3986.  [Link to Pubmed]
38. Yoshiie, K., Kim, H.Y., Mott, J., and Y. Rikihisa. (2000) Intracellular infection by human granulocytic ehrlichiosis agent inhibits human neutrophil apoptosis. Infect. Immun. 68: 1125-1133.  [Link to Pubmed]
39. Rikihisa, Y. (2000) Diagnosis of Emerging Ehrlichial Diseases of Dogs, Horses, and Humans. Editorial. J. Vet. Int. Med. 14: 250-251.  [Link to Pubmed]
40. Walker, D.H., J. Bakken, P. Brouqui, J. Childs, L. Cullman, J. Dawson, J.S. Dumler, V. Fingerle, J. Goodman, P. Hogan, W. Hogrefe, J. Liz, L.A. Magnarelli, J. Markley, R. Massung, E.J. Masters, C. Murphy, J. Olano, C. Padoock, M. Petrovec, Y. Rikihisa, S. Standaert, G. P. Wormser, X-Y. Yu, T.A. Zupanic. (2000) Consensus on Diagnosis of Human Ehrlichioses. ASM News. 66: 287-290.  [Link to Pubmed]
41. Kim, H.Y., and Y. Rikihisa. (2000) Expression of interleukin-1b, tumor necrosis factor-a, and IL-6 in human peripheral blood leukocytes exposed to viable human granulocytic ehrlichiosis agent or recombinant major surface antigen P44. Infect. Immun. 68: 3394-3402.  [Link to Pubmed]
42. Tajima, T., N. Zhi, Q. Lin, Y. Rikihisa, H.W. Horowitz, J. Ralfalli, G.P. Womser, and K. Hechemy. (2000) Enzyme-linked immunosorbent assay using major outer membrane protein of the human granulocytic ehrlichiosis agent. Clin. Diag. Lab. Immunol. 7: 652-657.  [Link to Pubmed]
43. Mott, J., and Y. Rikihisa. (2000) Human granulocytic ehrlichiosis agent inhibits superoxide anion generation by human neutrophils. Infect. Immun. 68: 6697-6703.  [Link to Pubmed]
44. Mott, J., R. Barnewall, and Y. Rikihisa. (1999) Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells. Infect. Immun. 67: 1368-1378.  [Link to Pubmed]
45. Zhi, N., N. Ohashi, and Y. Rikihisa. (1999) Multiple p44 genes encoding major outer membrane proteins are expressed in the human granulocytic ehrlichiosis agent. J. Biol. Chem. 274: 17828-17836.  [Link to Pubmed]
46. Horowitz, H.W., M.E. Aguero-Rosenfeld, D.F. McKenna, D. Holmgren, T-Z. Hsieh, S. A. Varde, S.J. Dumler, J. M. Wu, I. Schwartz, Y. Rikihisa, and G. P. Wormser. (1998) Clinical and laboratory spectrum of culture-proven human granulocytic ehrlichiosis Comparison with culture-negative cases. Clin. Infect. Dis. 27: 1314-1317.  [Link to Pubmed]
47. Zhi, N., N. Ohashi, Y. Rikihisa, H.W. Horowitz, G.P. Wormser, K. Hechemy. (1998) Cloning and expression of 44-kDa major outer membrane protein antigen gene of human granulocytic ehrlichiosis agent and application of the recombinant protein to serodiagnosis. J. Clin. Microbiol. 36: 1666-1673.  [Link to Pubmed]
48. Kim, H.Y., and Y. Rikihisa. (1998) Characterization of monoclonal antibodies against the major outer membrane protein of human granulocytic ehrlichiosis agent. J. Clin. Microbiol. 36: 3278-3284.  [Link to Pubmed]
49. Rikihisa, Y., N. Zhi, G. Wormser, B. Wen, H.W. Horowitz, and K.E. Hechemy. (1997) Direct isolation and cultivation of human granulocytic ehrlichia from a human patient. J. Infect. Dis. 175: 210-213.  [Link to Pubmed]
50. Zhi, N., Y. Rikihisa, H.Y. Kim, G.P. Wormser, and H.W. Horowitz. (1997) Comparison of major antigenic proteins of six strains of human granulocytic ehrlichiosis agents by Western immnoblot analysis. J. Clin. Microbiol. 35: 2606-2611.  [Link to Pubmed]

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