Selected Publications in Category - Ehrlichia chaffeensis (HME) :      Back to Publications Page   

1. Rikihisa, Y., M. Lin, H. Niu, and Z. Cheng. (2009) Type IV Secretion System of Anaplasma phagocytophilum and Ehrlichia chaffeensis. In: Rickettsiology and Rickettsial Diseases-Fifth International Conference. Edited by Karim E. Hechemy; Philippe Brouqui; James E. Samuel; and Didier A. Raoult. Ann. N. Y. Acad. Sci. 1166: 106-111. [Link to Pubmed]
2. Miura, K., and Y. Rikihisa. (2009) Liver microarray profiles associated with strain-specific Ehrlichia chaffeensis–induced hepatitis in mice. Infect. Immun. 77: 245-254.  [Link to Pubmed]
3. Bao, W.†, Y. Kumagai†, H. Niu, Y. Yamaguchi, K. Miura, and Y. Rikihisa. (†equally contributed) (2009) Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles. J. Bacteriol. 191: 278-286. [PMCID: PMC2612412] | [Link to Pubmed]
4. Delos Santos, J. R., M. Oglesbee M, Y. Rikihisa., R. W. Stich (2008) Pathologic Evidence of Ehrlichiosis in Calves Inoculated with Ehrlichia chaffeensis. Ann. N.Y. Acad. Sci. (Animal Biodiversity and Emerging Diseases) 1149: 103-106. [Link to Pubmed]
5. Cheng, Z., X. Wang, and Y. Rikihisa. (2008) Regulation of Type IV Secretion Apparatus Genes during Ehrlichia chaffeensis Intracellular Development by a Previously Unidentified Protein. J. Bacteriol. 190: 2096-2105. [PMCID: PMC2258868] | [Link to Pubmed]
6. Mottaz-Brewer, Heather M., A. D. Norbeck, J. N. Adkins, N. P. Manes, C. K. Ansong, L. Shi, Y. Rikihisa, T. Kikuchi, S. W. Wong, R. D. Estep, F. Heffron, L. Pasa-Tolic, and R. D. Smith. (2008) Optimization of proteomic sample preparation procedures for comprehensive protein characterization of pathogenic systems. J. Biomol. Tech. 19: 285-295. [PMCID: PMC2628077] | [Link to Pubmed]
7. Huang, H. †, M. Lin †, X. Wang, T. Kikuchi, H. Mottaz, A. Norbeck, and Y. Rikihisa. († Equally Contributed) (2008) Proteomic Analysis of and Immune Responses to Ehrlichia chaffeensis Lipoproteins. Infect. Immun. 76: 3405-3414. [PMCID: PMC2493228] | [Link to Pubmed]
8. Kumagai, Y., H. Huang, and Y. Rikihisa. (2008) Expression and Porin Activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis Development. J. Bacteriol. 190: 3597-3605. [PMCID: PMC2394992] | [Link to Pubmed]
9. Delos Santos, J.R., K. Boughan, W.G. Bremer, B. Rizzo B, J.J. Schaefer, Y. Rikihisa, G. R. Needham, L.A. Capitini, D. E. Anderson, M. Oglesbee, S.A. Ewing, R. W. Stich (2007) Experimental infection of dairy calves with Ehrlichia chaffeensis J. Med. Microbiol. 56: 1660-1668.  [Link to Pubmed]
10. Miura, K. and Y. Rikihisa. (2007) Virulence potential of Ehrlichia chaffeensis strains of distinct genome sequences. Infect. Immun. 75: 3604-3613. [PMCID: PMC1932932] | [Link to Pubmed]
11. Ge, Y. and Y. Rikihisa. (2007) Surface-exposed proteins of Ehrlichia chaffeensis. Infect. Immun. 75: 3833-3841. [PMCID: PMC1951975] | [Link to Pubmed]
12. Lin, M., and Y. Rikihisa. (2007) Degradation of p22phox and Inhibition of Superoxide Generation by Ehrlichia chaffeensis in Human Monocytes. Cell. Microbiol. 9: 861-874. [Link to Pubmed]
13. Kawahara, M, Y. Rikihisa, Q. Lin, E. Isogai, K. Tahara, A. Itagaki, Y. Hiramitsu, and T. Tajima. (2006) Genetic variants of Anaplasma phagocytophilum, Anaplasma bovis, Anaplasma centrale and Ehrlichia species in wild deer on two major islands in Japan. Appl. Environ. Microbiol. 72: 1102-1109. [PMCID: PMC1392898] | [Link to Pubmed]
14. Cheng, Z., Y. Kumagai, M. Lin, C. Zhang, and Y. Rikihisa. (2006) Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cell. Microbiol. 8: 1241-1252.  [Link to Pubmed]
15. Kumagai, Y., Z. Cheng, M. Lin, and Y. Rikihisa. (2006) Biochemical Activities of Three Pairs of Ehrlichia chaffeensis Two-Component Regulatory System Involved in Inhibition of Lysosomal Fusion. Infect. Immun. 74: 5014-5022. [PMCID: PMC1594868] | [Link to Pubmed]
16. Rikihisa, Y. (2006) Ehrlichia subversion of host innate immune responses. Curr. Opin. Microbiol. 9: 95-101.  [Link to Pubmed]
17. Dunning Hotopp, J., M. Lin, R. Madupu, J. Crabtree, S. Angiuoli, J. Eisen, R. Sesahdri, Q. Ren, T. R. Utterback, S. Smith, M. Lewis, H. Khouri, C. Zhang, H. Niu, Q. Lin, N. Ohashi, N. Zhi, W. Nelson, L. M. Brinkac, R. J. Dodson, M. J. Rosovitz, J. Sundaram, S. C. Daugherty, T. Davidsen, A. Durkin, M. Gwinn, D. H. Haft, J. D. Selengut, S.A. Sullivan, N. Zafar, L. Zhou, F. Benahmed, H. Forberger, R. Halpin, S. Mulligan, J. Robinson,Y. Rikihisa, H. Tettelin. (2006) Comparative Genomics of Emerging Human Ehrlichioisis Agents. PLoS Genetics 2: e21. [PMCID: PMC1366493] | [Link to Pubmed]
18. Lin, M., and Y. Rikihisa. (2004) Ehrlichia chaffeensis Downregulates Surface Toll-like Receptors 2/4, CD14, and Transcription Factors PU.1, and Inhibits LPS Activation of NF-kappaB, ERK 1/2, and p38 MAPK in Host Monocytes. Cell. Microbiol. 6: 175-186.  [Link to Pubmed]
19. Okada, H., H. Usuda, T. Tajima, M. Kawahara, T. Yoshino, and Y. Rikihisa. (2003) Detection and localization of Ehrlichia sp. HF strain most closely related to Ehrlichia chaffeensis in a mouse model by in situ hybridization. J. Comp. Pathol. 128: 182-187.  [Link to Pubmed]
20. Lin, M., and Y. Rikihisa. (2003) Ehrlichia chaffeensis and Anaplasma phagocytophilum Lack Genes for Lipid A Biosynthesis and Incorporate Cholesterol for Their Survival. Infect. Immun. 71: 5324-5331. [PMCID: PMC187327] | [Link to Pubmed]
21. Lin, M., and Y. Rikihisa. (2003) Obligatory intracellular parasitism by Ehrlichia chaffeensis and Anaplasma phagocytophilum involves caveolae and glycosylphosphatidylinositol-anchored proteins. Cell. Microbiol. 5: 809-820.  [Link to Pubmed]
22. Allison M. Liddell, John W. Sumner, Christopher D. Paddock, Y. Rikihisa, A. Unver, Richard S. Buller, and Gregory A. Storch. (2002) Reinfection with Ehrlichia chaffeensis in a Liver Transplant Recipient. Clin. Infect. Dis. 34: 1644-1647.  [Link to Pubmed]
23. Ohashi, N., N. Zhi, Q. Lin, and Y. Rikihisa. (2002) Characterization and Transcriptional Analysis of Gene Clusters for a Type IV Secretion Machinery in Human Granulocytic and Monocytic Ehrlichiosis Agents. Infect. Immun. 70: 2128-2138.  [Link to Pubmed]
24. Unver, A., Y. Rikihisa, R.W. Stich, N. Ohashi, and S. Felek. (2002) The omp-1 Major Outer Membrane Multigene Family of Ehrlichia chaffeensis is Differentially Expressed in Canine and Tick Hosts. Infect. Immun. 70: 4701-4704.  [Link to Pubmed]
25. Lin, M., Michael X. Zhu, and Y. Rikihisa. (2002) Rapid activation of PLC-gamma2, increase in cytosolic free calcium, recruitment of PLC-gamma2 and tyrosine phosphorylated proteins to its inclusion by Ehrlichia chaffeensis for internalization and growth in THP-1 cells. Infect. Immun. 70: 889-898. [PMCID: PMC127685] | [Link to Pubmed]
26. Okada, H., T. Tajima, M. Kawahara, and Y. Rikihisa. (2001) Ehrlichial proliferation in endothelial cells and lethal liver necrosis in immunocompetent mice experimentally infected with HF strain most closely related to Ehrlichia chaffeensis. J. Comp. Pathol. 124: 165-171.  [Link to Pubmed]
27. Ohashi, N., Y. Rikihisa, and A. Unver. (2001) Analysis of transcriptionally active gene clusters of major outer membrane protein multigene family in Ehrlichia canis and E. chaffeensis. Infect. Immun. 69: 2083-2091.  [Link to Pubmed]
28. Dumler, J.S., A.F. Barbet, C.P.J. Bekker, G.A. Dasch, G.H. Palmer, S.C. Ray, Y. Rikihisa, and F. R. Rurangirwa. (2001) Reorganization of Genera in the Families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales; Unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia, and Ehrlichia with Neorickettsia; Description of six new species combinations; and Designation of Ehrlichia equi and "HGE agent" as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51: 2145-2165.  [Link to Pubmed]
29. Unver, A., S. Felek, N. Zhi, C. Paddock, H. W. Horowitz, G. P.Wormser, and Y. Rikihisa. (2001) Western Immunoblot Analysis of HME and HGE dual reactive sera. J. Clin. Microbiol. 39: 3982-3986.  [Link to Pubmed]
30. Shibata, S., M. Kawahara, Y. Rikihisa, H. Fujita, Y. Watanabe, C. Suto, and T. Ito. (2000) New Ehrlichia sp. closely related with E. chaffeensis isolated from Ixodes ovatus ticks in Japan. J. Clin. Microbiol. 38: 1331-1338.  [Link to Pubmed]
31. Rikihisa, Y. (2000) Diagnosis of Emerging Ehrlichial Diseases of Dogs, Horses, and Humans. Editorial. J. Vet. Int. Med. 14: 250-251.  [Link to Pubmed]
32. Walker, D.H., J. Bakken, P. Brouqui, J. Childs, L. Cullman, J. Dawson, J.S. Dumler, V. Fingerle, J. Goodman, P. Hogan, W. Hogrefe, J. Liz, L.A. Magnarelli, J. Markley, R. Massung, E.J. Masters, C. Murphy, J. Olano, C. Padoock, M. Petrovec, Y. Rikihisa, S. Standaert, G. P. Wormser, X-Y. Yu, T.A. Zupanic. (2000) Consensus on Diagnosis of Human Ehrlichioses. ASM News. 66: 287-290.  [Link to Pubmed]
33. Mott, J., R. Barnewall, and Y. Rikihisa. (1999) Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells. Infect. Immun. 67: 1368-1378.  [Link to Pubmed]
34. Rikihisa, Y. (1999) Clinical and biological aspects of infections caused by Ehrlichia chaffeensis. Microb. Infect. 1: 367-376.  [Link to Pubmed]
35. Unver, A., Y. Rikihisa, N. Ohashi. (1999) Western and dot blotting analysis of Ehrlichia chaffeensis IFA-positive and negative sera using native and recombinant E. chaffeensis and E. canis antigen. J. Clin. Microbiol. 37: 3888-3895.  [Link to Pubmed]
36. Ohashi, N., N. Zhi, Y. Zhang, and Y. Rikihisa. (1998) Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family. Infect. Immun. 66: 132-139.  [Link to Pubmed]
37. Lee, E. and Y. Rikihisa. (1998) Protein kinase A-mediated inhibition of interferon-gamma-induced tyrosine phosphorylation of Janus kinases and latent cytoplasmic transcription factors in human monocytes by Ehrlichia chaffeensis. Infect. Immun. 66: 2514-2520.  [Link to Pubmed]
38. Barnewall, R.E., Y. Rikihisa, and E.H. Lee. (1997) Ehrlichia chaffeensis inclusions are early endosomes which selectively accumulate transferrin receptor. Infect. Immun. 65: 1455-1461.  [Link to Pubmed]
39. Lee, E.H. and Y. Rikihisa. (1997) Anti-Ehrlichia chaffeensis antibody induces potent proinflammatory cytokine mRNA expression in human monocytes exposed to E. chaffeensis through sustained reduction of IkB-a and activation of NF-kB. Infect. Immun. 65: 2890-2897.  [Link to Pubmed]
40. Zhang, Y. and Y. Rikihisa. (1997) Tyrosine phosphorylation is required for ehrlichial Internalization and replication in P388D1 cells. Infect. Immun. 65: 2959-2964.  [Link to Pubmed]
41. Lee, E. and Y. Rikihisa. (1996) Absence of TNF-a, IL-6, and GM-CSF but presence of IL-1b, IL-8, and IL-10 expression in human monocytes exposed to viable or killed Ehrlichia chaffeensis. Infect. Immun. 64: 4211-4219.  [Link to Pubmed]
42. Rikihisa, Y., Y. Zhang, and J. Park. (1995) Role of Ca2+ and calmodulin on ehrlichial survival in macrophages. Infect. Immun. 63: 2310-2316.  [Link to Pubmed]
43. Rikihisa, Y., S.A. Ewing, and J.C. Fox. (1994) Western immunoblot analysis of Ehrlichia chaffeensis, E. canis, or E. ewingii infection of dogs and human. J. Clin. Microbiol. 32: 2107-2112.  [Link to Pubmed]
44. Barnewall, R. and Y. Rikihisa. (1994) Abrogation of interferon-g induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron transferrin. Infect. Immun. 62: 4804-4810.  [Link to Pubmed]

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