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Current Research Projects:
Our currently funded research projects include:
- Molecular and Cellular Mechanism of Invasion/Replication of Intracellular
Bacteria
- Signal Transduction Altered by Intracellular Bacteria
- Signal Transduction induced by Intracellular Bacteria upon interaction with
host cells
- Role of Cytokines and Antibodies in Ehrlichial Diseases.
- Molecular and Antigenic Characterization of Ehrlichia, Anaplasma,
and Neorickettsia spp.
- Ehrlichial diseases; Potomac horse fever, canine ehrlichiosis, human monocytic
ehrlichiosis, human granulocytic ehrlichiosis. Diagnosis: PCR, dot blot, Western
blot, IFA, ELISA, isolation of ehrlichiosis, cloning ehrlichial major antigens.
- Cloning of major outer membrane proteins of ehrlichiae and examining the gene
expression in different hosts (vertebrate and non-vertebrate).
- Comparison of 3 Human Ehrlichiosis Agent Genome Sequences: 1) Determination
of the complete nucleotide sequence of Ehrlichia chaffeensis, Anaplasma
phagocyophila, and Neorickettisa sennetsu; 2) Comparison of these
three sequences and DNA microarray analysis.
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